Sinn N
CSIRO Human Nutrition, University of South Australia, Adelaide, Australia.
Prostaglandins Leukot Essent Fatty Acids. 2007 Aug;77(2):109-15. doi: 10.1016/j.plefa.2007.08.002. Epub 2007 Sep 6.
Fatty acid deficiency symptoms (FADS) of dry hair and skin, frequent thirst and urination have been observed to be higher in children with attention deficit hyperactivity disorder (ADHD). Two studies investigated FADS in 7-12-year-old children; Study 1 in a general population (N=347) and Study 2 in children with ADHD symptoms (N=104). Correlations between FADS and ADHD-related symptoms were found at baseline in Study 1 but not Study 2. FADS did not improve after supplementation with omega-3 and omega-6 polyunsaturated fatty acids (PUFA) versus placebo after 15 weeks in Study 2, and were not related to improvements in ADHD symptoms in the PUFA groups. However, FADS did improve in all groups, possibly attributable to the linoleic acid present in both the PUFA and placebo (palm oil) supplements. FADS are not a reliable selection criterion for children with ADHD who might benefit from omega-3 PUFA supplementation.
在患有注意力缺陷多动障碍（ADHD）的儿童中，观察到脂肪酸缺乏症状（FADS），如头发干燥、皮肤干燥、频繁口渴和排尿的情况更为常见。两项研究对7至12岁儿童的脂肪酸缺乏症状进行了调查；研究1针对普通人群（N = 347），研究2针对有ADHD症状的儿童（N = 104）。在研究1的基线时发现了脂肪酸缺乏症状与ADHD相关症状之间的相关性，但在研究2中未发现。在研究2中，与安慰剂相比，补充ω-3和ω-6多不饱和脂肪酸（PUFA）15周后，脂肪酸缺乏症状并未改善，且与PUFA组中ADHD症状的改善无关。然而，所有组的脂肪酸缺乏症状均有所改善，这可能归因于PUFA和安慰剂（棕榈油）补充剂中都含有的亚油酸。对于可能从ω-3 PUFA补充剂中受益的ADHD儿童，脂肪酸缺乏症状并不是一个可靠的选择标准。
