Aben A, Danckaerts M
Tijdschr Psychiatr. 2010;52(2):89-97.
Background There is a growing trend towards the use of alternative forms of treatment for attention deficit hyperactivity disorder (adhd), such as the food supplements omega-3 and omega-6 fatty acids.
To study biochemical aspects, important hypotheses regarding the role of these fatty acids in brain development, the mode of operation and research results concerning the effectiveness of treating adhd with these supplements.
A Medline search was performed using the Mesh-term 'fatty acids' and the search terms 'omega-3 and omega-6 fatty acids' and 'attention deficit hyperactivity disorder'. results Some rct's (randomised controlled trails) involving children with adhd didn't show any improvement after treatment with omega-3 and omega-6 fatty acids. Some other rct's, however, did show a reduction in adhd symptoms and learning difficulties, but the children concerned had not been officially diagnosed with adhd. A recent rct showed a substantial reduction in adhd symptoms in children with the inattentive type of adhd and in children with adhd and comorbid problems.
There are indications that there is a theoretical rationale for the effectiveness of fatty acids in the treatment of adhd; research is ongoing. At the moment, however, treatment of adhd with omega-3 and omega-6 fatty acids is not recommended because it does not qualify as being evidence-based.
背景 对于注意力缺陷多动障碍（ADHD），使用替代治疗形式的趋势日益增长，例如食品补充剂ω-3和ω-6脂肪酸。
研究这些脂肪酸在大脑发育中的作用、作用方式以及使用这些补充剂治疗ADHD有效性的重要假设的生化方面和研究结果。
使用主题词“脂肪酸”以及检索词“ω-3和ω-6脂肪酸”和“注意力缺陷多动障碍”进行Medline检索。结果 一些涉及ADHD儿童的随机对照试验（RCT）在使用ω-3和ω-6脂肪酸治疗后未显示出任何改善。然而，其他一些随机对照试验确实显示ADHD症状和学习困难有所减轻，但相关儿童未被正式诊断为ADHD。最近一项随机对照试验显示，注意力不集中型ADHD儿童以及患有ADHD和共病问题的儿童的ADHD症状大幅减轻。
有迹象表明脂肪酸治疗ADHD的有效性存在理论依据；研究正在进行中。然而，目前不建议使用ω-3和ω-6脂肪酸治疗ADHD，因为它不符合循证医学的标准。
