丙型肝炎病毒生命周期

Hepatitis C viral life cycle.

作者信息

Suzuki Tetsuro, Ishii Koji, Aizaki Hideki, Wakita Takaji

机构信息

Department of Virology II, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

出版信息

Adv Drug Deliv Rev. 2007 Oct 10;59(12):1200-12. doi: 10.1016/j.addr.2007.04.014. Epub 2007 Aug 9.

DOI:10.1016/j.addr.2007.04.014

PMID:17825945

Abstract

Hepatitis C virus (HCV) has been recognized as a major cause of chronic liver diseases worldwide. Molecular studies of the virus became possible with the successful cloning of its genome in 1989. Although much work remains to be done regarding early and late stages of the HCV life cycle, significant progress has been made with respect to the molecular biology of HCV, especially the viral protein processing and the genome replication. This review summarizes our current understanding of genomic organization of HCV, features of the viral protein characteristics, and the viral life cycle.

摘要

丙型肝炎病毒（HCV）已被公认为全球慢性肝病的主要病因。随着1989年该病毒基因组的成功克隆，对其进行分子研究成为可能。尽管在丙型肝炎病毒生命周期的早期和晚期仍有许多工作要做，但在丙型肝炎病毒的分子生物学方面，特别是病毒蛋白加工和基因组复制方面，已经取得了重大进展。本综述总结了我们目前对丙型肝炎病毒基因组结构、病毒蛋白特征以及病毒生命周期的理解。