O'Dwyer Martin, Day Adam, Padgett Miles, Ogden G R, McLaren S, Goodman Carol R
Department of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.
Br J Oral Maxillofac Surg. 2008 Jan;46(1):6-10. doi: 10.1016/j.bjoms.2007.05.009. Epub 2007 Sep 7.
Patients who have had one oral cancer are at increased risk of developing a further malignant tumour, the detection of which is made difficult (and is often delayed) by the innocuous appearance of the early oral lesion. A technique that could reliably detect early cancers would be useful to both oral and dental health specialists. We describe a pilot study in which we used a compact spectroscopic instrument designed to excite and measure fluorescence in the oral cavity. The data were processed using principal components analysis, and the results suggest that the technique might be valuable for detecting early oral cancers. Further work should be performed to investigate some unusual characteristics observed within our data to ascertain if these are significant, simply due to errors made due data collection, or are due to other lifestyle factors. Such work could also verify that the data are due to detection of ALA metabolite in cancer and not some other systemic effect.
曾患口腔癌的患者发生进一步恶性肿瘤的风险增加，早期口腔病变外观无害，使得此类肿瘤的检测变得困难（且常常延迟）。一种能够可靠检测早期癌症的技术对口腔和牙科健康专家均有用处。我们描述了一项试点研究，在该研究中我们使用了一种紧凑型光谱仪器，旨在激发并测量口腔内的荧光。数据采用主成分分析进行处理，结果表明该技术可能对检测早期口腔癌有价值。应开展进一步工作，以研究我们数据中观察到的一些异常特征，确定这些特征是具有显著性，仅仅是由于数据收集过程中出现的错误，还是由于其他生活方式因素。此类工作还可验证数据是因检测到癌症中的ALA代谢物所致，而非其他某种全身效应。
