腋窝超声及细针穿刺活检在评估乳腺浸润性小叶癌中的应用价值
Utility of ultrasound and fine-needle aspiration biopsy of the axilla in the assessment of invasive lobular carcinoma of the breast.
作者信息
Boughey Judy C, Middleton Lavinia P, Harker Lori, Garrett Betsy, Fornage Bruno, Hunt Kelly K, Babiera Gildy V, Dempsey Peter, Bedrosian Isabelle
机构信息
Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, 1400 Holcombe Blvd, Houston, TX 77030, USA.
出版信息
Am J Surg. 2007 Oct;194(4):450-5. doi: 10.1016/j.amjsurg.2007.06.017.
BACKGROUND
The unique growth pattern of invasive lobular carcinoma (ILC) poses a challenge for preoperative assessment of disease extent within the breast. Whether it similarly limits lymph node staging by ultrasound (US) and fine-needle aspiration (FNA) biopsy was the subject of the current study.
METHODS
A total of 217 patients with ILC who underwent axillary US were reviewed. FNA biopsy was performed when US findings were suspicious or indeterminate. Findings were compared to literature reports of US in invasive ductal carcinoma (IDC) patients.
RESULTS
Axillary US was negative in 137 patients (63%) and suspicious or indeterminate in 80 patients (37%). FNA biopsy was positive in 62% (47/76 patients). Preoperative US and FNA biopsy identified 43 of 111 (39%) node-positive patients. Sensitivity of US with FNA biopsy correlated with primary tumor and nodal metastasis size. Similar results were seen in IDC populations.
CONCLUSION
US with FNA biopsy appears to be similarly useful in axillary staging of ILC and IDC patients.
背景
浸润性小叶癌（ILC）独特的生长模式对术前评估乳腺内疾病范围构成挑战。它是否同样限制了超声（US）和细针穿刺抽吸（FNA）活检对淋巴结的分期是本研究的主题。
方法
回顾了217例接受腋窝超声检查的ILC患者。当超声检查结果可疑或不确定时，进行FNA活检。将结果与浸润性导管癌（IDC）患者超声检查的文献报告进行比较。
结果
137例患者（63%）腋窝超声检查结果为阴性，80例患者（37%）为可疑或不确定。FNA活检阳性率为62%（47/76例患者）。术前超声和FNA活检确诊了111例淋巴结阳性患者中的43例（39%）。超声联合FNA活检的敏感性与原发肿瘤及淋巴结转移大小相关。在IDC人群中也观察到类似结果。
结论
超声联合FNA活检在ILC和IDC患者腋窝分期中似乎同样有用。
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