Pope-Harman Amy, Cheng Mark Ming-Cheng, Robertson Fredika, Sakamoto Jason, Ferrari Mauro
Dorothy M. Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA.
Med Clin North Am. 2007 Sep;91(5):899-927. doi: 10.1016/j.mcna.2007.05.008.
Nanotechnology may hold the key to controlling many devastating diseases. In the fight against the pain, suffering, and death due to cancer, nanotechnology will allow earlier diagnosis and even prevention of malignancy at premalignant stages, in addition to providing multimodality treatment not possible with current conventional techniques. This review discusses nanotechnology already used in diagnostic and therapeutic applications for cancer. Also addressed are theoretic and evolving uses of nanotechnology, including multifunctional nanoparticles for imaging and therapy, nanochannel implants for controlled release of drugs, nanoscale devices for evaluation of proteomics and genomics, and diagnostic techniques that take advantage of physical changes in diseased tissue.
纳米技术可能是控制许多毁灭性疾病的关键所在。在对抗因癌症所致的疼痛、痛苦和死亡的斗争中,纳米技术不仅能够提供当前传统技术所无法实现的多模态治疗,还能实现更早的诊断,甚至在癌前阶段预防恶性肿瘤。这篇综述讨论了已用于癌症诊断和治疗应用的纳米技术。还阐述了纳米技术的理论及不断发展的用途,包括用于成像和治疗的多功能纳米颗粒、用于药物控释的纳米通道植入物、用于蛋白质组学和基因组学评估的纳米级装置,以及利用患病组织物理变化的诊断技术。