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新兴纳米药物

Emerging nanopharmaceuticals.

作者信息

Bawarski Willie E, Chidlowsky Elena, Bharali Dhruba J, Mousa Shaker A

机构信息

Pharmaceutical Research Institute at Albany College of Pharmacy, Rensselaer, New York, USA.

出版信息

Nanomedicine. 2008 Dec;4(4):273-82. doi: 10.1016/j.nano.2008.06.002. Epub 2008 Jul 18.

Abstract

A budding interest in nanopharmaceuticals has generated a number of advancements throughout recent years with a focus on engineering novel applications. Nanotechnology also offers the ability to detect diseases at much earlier stages, such as finding hidden or overt metastatic colonies often seen in patients diagnosed with breast, lung, colon, prostate, and ovarian cancer. Diagnostic applications could build upon conventional procedures using nanoparticles, such as colloidal gold, iron oxide crystals, and quantum dots. Additionally, diseases may be managed by multifunctional agents encompassing both imaging and therapeutic capabilities, thus allowing simultaneous monitoring and treatment. A detailed evaluation of each formulation is essential to expand our current nanopharmaceutical repertoire. However, the safety and long-term effects of nanoformulations must not be overlooked. This review will provide a brief discussion of the major nanopharmaceutical formulations as well as the impact of nanotechnology into the future.

摘要

近年来,人们对纳米药物的兴趣日益浓厚,取得了许多进展,重点是设计新颖的应用。纳米技术还能够在更早的阶段检测疾病,比如发现患有乳腺癌、肺癌、结肠癌、前列腺癌和卵巢癌的患者中常见的隐匿或明显的转移瘤。诊断应用可以基于使用纳米颗粒的传统程序,如胶体金、氧化铁晶体和量子点。此外,疾病可以通过兼具成像和治疗能力的多功能制剂来控制,从而实现同步监测和治疗。对每种制剂进行详细评估对于扩充我们当前的纳米药物储备至关重要。然而,纳米制剂的安全性和长期影响不容忽视。本综述将简要讨论主要的纳米药物制剂以及纳米技术对未来的影响。

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