Kanayama Sugako, Matsunari Ichiro, Kajinami Koji
Department of Internal Medicine, Saiseikai Takaoka Hospital, Takaoka, Japan.
J Nucl Cardiol. 2007 Sep-Oct;14(5):680-7. doi: 10.1016/j.nuclcard.2007.05.011.
The aim of this study was to compare global and regional left ventricular function in patients with coronary artery disease (CAD), obtained by use of Cedars-Sinai quantitative gated single photon emission computed tomography (QGS), for gated nitrogen 13 ammonia (NH(3)) positron emission tomography (PET) and technetium 99m sestamibi (MIBI) single photon emission computed tomography (SPECT).
Fifty-one patients with CAD underwent gated N-13 NH(3) PET and gated MIBI SPECT. The end-diastolic volume, end-systolic volume, and ejection fraction were calculated by use of QGS. The quantitative regional wall motion (WM) and wall thickening (WT) scores for 20 segments in the myocardium were also measured by QGS. The end-diastolic volume, end-systolic volume, and ejection fraction measured by N-13 NH(3) PET showed highly significant correlation with those measured by MIBI SPECT (r = 0.97, r = 0.97, and r = 0.84, respectively). The mean correlation of WM and WT on an individual patient basis between N-13 NH(3) PET and MIBI SPECT was 0.81 and 0.84, respectively. The circumferential variation of WM and WT in 20 segments showed a similar pattern with N-13 NH(3) PET and MIBI SPECT.
Gated N-13 NH(3) PET combined with QGS provides information on both global and regional left ventricular function comparable to that obtained by gated Tc-99m perfusion myocardial SPECT in CAD patients.
本研究旨在比较使用雪松西奈定量门控单光子发射计算机断层扫描（QGS）对冠心病（CAD）患者进行门控氮13氨（NH₃）正电子发射断层扫描（PET）和锝99m甲氧基异丁基异腈（MIBI）单光子发射计算机断层扫描（SPECT）时，左心室的整体和局部功能。
51例CAD患者接受了门控N - 13 NH₃ PET和门控MIBI SPECT检查。通过QGS计算舒张末期容积、收缩末期容积和射血分数。还通过QGS测量心肌中20个节段的定量局部壁运动（WM）和壁增厚（WT）评分。N - 13 NH₃ PET测量的舒张末期容积、收缩末期容积和射血分数与MIBI SPECT测量的结果显示出高度显著的相关性（分别为r = 0.97、r = 0.97和r = 0.84）。在个体患者基础上，N - 13 NH₃ PET和MIBI SPECT之间WM和WT的平均相关性分别为0.81和0.84。20个节段中WM和WT的圆周变化在N - 13 NH₃ PET和MIBI SPECT上显示出相似的模式。
门控N - 13 NH₃ PET联合QGS提供的左心室整体和局部功能信息，与CAD患者门控Tc - 99m灌注心肌SPECT所获得的信息相当。
