De Stefano Alessandro, Dispenza Francesco, De Donato Giuseppe, Caruso Antonio, Taibah Abdelkader, Sanna Mario
Clinica ORL, Università G. d'Annunzio, Chieti-Pescara, Italy.
Am J Otolaryngol. 2007 Sep-Oct;28(5):289-93. doi: 10.1016/j.amjoto.2006.09.009.
The objective of this study was to assess the usefulness of low-dose intratympanic gentamicin administration in patients with Meniere's disease (MD).
We carried out a retrospective review of the charts of 55 patients with definite MD in accordance with the AAO-HNS (American Academy of Otolaryngology-Head and Neck Surgery) Diagnostic Scale who were treated at Gruppo Otologico (Piacenza, Rome, Italy). The treatment protocol consisted of 3 intratympanic injections of gentamicin at a 12-hour interval between each administration.
Results were resumed in accordance with AAO-HNS criteria and showed complete control of vertigo spells in 60% (class A), good control in 16% (class B), moderate control in 4% (class C), poor control in 16% (class D), and no control in 4% (class E) of the patients. Audiological assessment showed unchanged thresholds in 61%, improvement in 22%, and worsening in 17% of the cases.
Administration of gentamicin is a good alternative to medical and surgical procedures in the treatment of intractable MD. One-day treatment allows for adequate control of vertigo attacks without compromising hearing and quality of life and with reduced costs.
本研究的目的是评估低剂量鼓室内注射庆大霉素对梅尼埃病（MD）患者的有效性。
我们根据美国耳鼻咽喉头颈外科学会（AAO-HNS）诊断标准，对在意大利皮亚琴察、罗马的Gruppo Otologico接受治疗的55例确诊MD患者的病历进行了回顾性研究。治疗方案为每12小时进行3次鼓室内庆大霉素注射。
根据AAO-HNS标准汇总结果，显示60%的患者眩晕发作得到完全控制（A类），16%的患者得到良好控制（B类），4%的患者得到中度控制（C类），16%的患者控制不佳（D类），4%的患者未得到控制（E类）。听力学评估显示，61%的病例阈值未变，22%的病例有所改善，17%的病例恶化。
庆大霉素给药是治疗难治性MD的药物和手术方法的良好替代方案。一日治疗可充分控制眩晕发作，同时不损害听力和生活质量，并降低成本。
