热休克蛋白90——从信号转导到细胞转化
Hsp90--from signal transduction to cell transformation.
作者信息
Brown Mark A, Zhu Li, Schmidt Christian, Tucker Philip W
机构信息
Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, The University of Texas at Austin, 1 University Station A5000, Austin, TX 78712, USA.
出版信息
Biochem Biophys Res Commun. 2007 Nov 16;363(2):241-6. doi: 10.1016/j.bbrc.2007.08.054. Epub 2007 Aug 20.
Abstract
The molecular chaperone, Hsp90, facilitates the maturation and/or activation of over 100 'client proteins' involved in signal transduction and transcriptional regulation. Largely an enigma among the families of heat shock proteins, Hsp90 is central to processes broadly ranging from cell cycle regulation to cellular transformation. Here, we review the contemporary body of knowledge regarding the biochemical mechanisms of Hsp90 and update the most current paradigms defining its involvement in both normal and pathological cell physiology.
摘要
分子伴侣Hsp90促进了100多种参与信号转导和转录调控的“客户蛋白”的成熟和/或激活。Hsp90在热休克蛋白家族中很大程度上仍是一个谜，它在从细胞周期调控到细胞转化等广泛过程中起着核心作用。在此，我们综述了关于Hsp90生化机制的当代知识体系，并更新了定义其在正常和病理细胞生理学中作用的最新范式。
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