Tan X M
Department of Pathology, West China Medical University.
Zhonghua Bing Li Xue Za Zhi. 1991 Sep;20(3):187-9.
Forty-six cases of mesotheliomas of rats induced by asbestos, 2 cases of human mesotheliomas and 10 cases of adenocarcinomas were studied by light microscopy, electron microscopy, histochemical and immunohistochemical staining. The results indicated that mesothelioma probably originates from the multipotential subserosal cell which has the features of myofibroblast. In addition to the epithelial, fibrous and mixed types of mesothelioma classified by WHO, poorly differentiated type of mesothelioma can also be found in rats. Electron microscopy, histochemical and immunohistochemical staining are very helpful in differentiating mesotheliomas from adenocarcinomas.
对46例由石棉诱发的大鼠间皮瘤、2例人类间皮瘤和10例腺癌进行了光镜、电镜、组织化学和免疫组织化学染色研究。结果表明，间皮瘤可能起源于具有肌成纤维细胞特征的多能浆膜下细胞。除了世界卫生组织分类的上皮型、纤维型和混合型间皮瘤外，在大鼠中还可发现低分化型间皮瘤。电镜、组织化学和免疫组织化学染色对鉴别间皮瘤和腺癌非常有帮助。
