McGrath Deirdre M, Naish Josephine H, O'Connor James P B, Hutchinson Charles E, Waterton John C, Taylor Chris J, Parker Geoffrey J M
Imaging Science and Biomedical Engineering, University of Manchester, Oxford Road, Manchester M13 9 PT, UK.
Magn Reson Imaging. 2008 Feb;26(2):221-7. doi: 10.1016/j.mri.2007.06.011. Epub 2007 Sep 10.
The objective was to measure the effect of 100% oxygen inhalation on T1 relaxation times in skeletal muscle. Healthy volunteers were scanned using three different MRI protocols while breathing medical air and 100% oxygen. Measurements of T1 were made from regions of interest (ROIs) within various skeletal muscle groups. Dynamic data of subjects breathing a sequence of air-oxygen-air allowed the calculation of characteristic wash-in and -out times for dissolved oxygen in muscle. Contrary to previous findings, a statistically significant decrease in T1 in skeletal muscle was observed due to oxygen inhalation. We report approximate baseline characteristic values for the response of skeletal muscle to oxygen inhalation. This measurement may provide new biomarkers for evaluation of oxygen delivery and consumption in normal and diseased skeletal muscle.
目的是测量吸入100%氧气对骨骼肌T1弛豫时间的影响。健康志愿者在呼吸医用空气和100%氧气时，使用三种不同的MRI协议进行扫描。从不同骨骼肌群内的感兴趣区域（ROI）进行T1测量。受试者呼吸空气-氧气-空气序列的动态数据允许计算肌肉中溶解氧的特征性吸入和呼出时间。与先前的研究结果相反，观察到由于吸入氧气，骨骼肌中的T1有统计学意义的下降。我们报告了骨骼肌对吸入氧气反应的近似基线特征值。这种测量可能为评估正常和患病骨骼肌中的氧气输送和消耗提供新的生物标志物。
