Gerez Juan, Bonfiglio José, Sosa Sebastian, Giacomini Damiana, Acuña Matias, Nagashima Alberto Carbia, Perone Marcelo J, Silberstein Susana, Renner Ulrich, Stalla Günter K, Arzt Eduardo
Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología y Biología Molecular y Celular, FCEN, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina.
Exp Physiol. 2007 Sep;92(5):801-6. doi: 10.1113/expphysiol.2007.036236.
Highly sophisticated mechanisms confer on the immune system the capacity to respond with a certain degree of autonomy. However, the final outcome of an immune response depends on the interaction of the immune system with other systems. The immune and neuroendocrine systems have an intimate cross-communication that makes possible a satisfactory response to environmental changes. Part of this interaction occurs through cytokines and steroid hormones. The last step of this cross-talk is the molecular level. As a model of interaction, this review focuses on the gp130 cytokine family. These cytokines, as well as their receptors, are expressed in pituitary cells. They regulate hormone production as well as growth of pituitary cells. During acute or chronic inflammation or infection, systemic, hypothalamic and hypophyseal gp130 cytokines act on anterior pituitary cells, integrating the neuroendocrine-immune response. Disruptions of these pathways may lead not only to abnormal growth of pituitary cells but also to immune disorders, for which, based on recent findings, targeting these cytokines might be a novel therapeutic approach.
高度复杂的机制赋予免疫系统一定程度的自主反应能力。然而，免疫反应的最终结果取决于免疫系统与其他系统的相互作用。免疫和神经内分泌系统存在密切的交叉通讯，这使得对环境变化能够做出令人满意的反应成为可能。这种相互作用的一部分是通过细胞因子和类固醇激素发生的。这种相互作用的最后一步发生在分子水平。作为相互作用的一个模型，本综述聚焦于gp130细胞因子家族。这些细胞因子及其受体在垂体细胞中表达。它们调节垂体细胞的激素产生以及生长。在急性或慢性炎症或感染期间，全身、下丘脑和垂体的gp130细胞因子作用于垂体前叶细胞，整合神经内分泌免疫反应。这些途径的破坏不仅可能导致垂体细胞异常生长，还可能导致免疫紊乱，基于最近的研究发现，针对这些细胞因子可能是一种新的治疗方法。
