抗凋亡蛋白Api5及其伴侣高分子量FGF2在B细胞慢性淋巴细胞白血病中上调。 - Suppr

The antiapoptotic protein Api5 and its partner, high molecular weight FGF2, are up-regulated in B cell chronic lymphoid leukemia.

作者信息

Krejci Pavel, Pejchalova Katerina, Rosenbloom Barry E, Rosenfelt Fred P, Tran Elizabeth L, Laurell Henrik, Wilcox William R

出版信息

J Leukoc Biol. 2007 Dec;82(6):1363-4. doi: 10.1189/jlb.0607425. Epub 2007 Sep 7.

DOI:10.1189/jlb.0607425

PMID:17827341

Abstract

摘要

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The antiapoptotic protein Api5 and its partner, high molecular weight FGF2, are up-regulated in B cell chronic lymphoid leukemia.抗凋亡蛋白Api5及其伴侣高分子量FGF2在B细胞慢性淋巴细胞白血病中上调。

J Leukoc Biol. 2007 Dec;82(6):1363-4. doi: 10.1189/jlb.0607425. Epub 2007 Sep 7.

Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells.紫草素通过ROS/JNK介导的过程诱导Bcr/Abl阳性慢性粒细胞白血病（CML）细胞凋亡。

Cell Res. 2008 Aug;18(8):879-88. doi: 10.1038/cr.2008.86.

Regulation of mRNA export through API5 and nuclear FGF2 interaction.通过 API5 和核 FGF2 相互作用调节 mRNA 输出。

Nucleic Acids Res. 2020 Jun 19;48(11):6340-6352. doi: 10.1093/nar/gkaa335.

[Kinetics of proliferation, differentiation and transcription of genes regulating apoptosis in cultured human BCR/ABL+ Ph+-cells].[培养的人BCR/ABL+ Ph+细胞中调节细胞凋亡的基因的增殖、分化及转录动力学]

Tsitologiia. 2007;49(10):889-900.

Phosphorylation levels of BCR-ABL, CrkL, AKT and STAT5 in imatinib-resistant chronic myeloid leukemia cells implicate alternative pathway usage as a survival strategy.伊马替尼耐药的慢性髓性白血病细胞中BCR-ABL、CrkL、AKT和STAT5的磷酸化水平表明，使用替代途径是一种生存策略。

Leuk Res. 2008 Apr;32(4):643-9. doi: 10.1016/j.leukres.2007.08.009. Epub 2007 Sep 27.

RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis.

FEBS Lett. 2007 Oct 30;581(26):5075-81. doi: 10.1016/j.febslet.2007.09.052. Epub 2007 Oct 2.

Inhibition of Abl tyrosine kinase enhances nerve growth factor-mediated signaling in Bcr-Abl transformed cells via the alteration of signaling complex and the receptor turnover.抑制Abl酪氨酸激酶可通过改变信号复合物和受体周转来增强神经生长因子介导的Bcr-Abl转化细胞中的信号传导。

Oncogene. 2008 Aug 7;27(34):4678-89. doi: 10.1038/onc.2008.107. Epub 2008 Apr 21.

The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells.新型吡咯并-1,5-苯并二氮杂卓PBOX-21可增强STI571（甲磺酸伊马替尼）对人慢性髓性白血病细胞的凋亡作用。

Biochem Pharmacol. 2009 Feb 1;77(3):310-21. doi: 10.1016/j.bcp.2008.10.008. Epub 2008 Oct 30.

Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation.雷公藤甲素抑制Bcr-Abl转录并诱导携带T315I突变的STI571耐药慢性粒细胞白血病细胞凋亡。

Clin Cancer Res. 2009 Mar 1;15(5):1686-97. doi: 10.1158/1078-0432.CCR-08-2141. Epub 2009 Feb 24.

N-acetyl cysteine enhances imatinib-induced apoptosis of Bcr-Abl+ cells by endothelial nitric oxide synthase-mediated production of nitric oxide.N-乙酰半胱氨酸通过内皮型一氧化氮合酶介导的一氧化氮生成增强伊马替尼诱导的Bcr-Abl+细胞凋亡。

Apoptosis. 2009 Mar;14(3):298-308. doi: 10.1007/s10495-008-0305-7.

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Combining multiomics to analyze the molecular mechanism of hair follicle cycle change in cashmere goats from Inner Mongolia.结合多组学分析内蒙古绒山羊毛囊周期变化的分子机制。

Front Vet Sci. 2024 Jul 5;11:1405355. doi: 10.3389/fvets.2024.1405355. eCollection 2024.

Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate.凋亡抑制因子5：细胞命运的多面调节因子

Biomolecules. 2024 Jan 22;14(1):136. doi: 10.3390/biom14010136.

Pan-Cancer Analysis Reveals the Prognostic Potential of the THAP9/THAP9-AS1 Sense-Antisense Gene Pair in Human Cancers.泛癌分析揭示了THAP9/THAP9-AS1正义-反义基因对在人类癌症中的预后潜力。

Noncoding RNA. 2022 Jul 8;8(4):51. doi: 10.3390/ncrna8040051.

Regulation of mRNA export through API5 and nuclear FGF2 interaction.通过 API5 和核 FGF2 相互作用调节 mRNA 输出。

Nucleic Acids Res. 2020 Jun 19;48(11):6340-6352. doi: 10.1093/nar/gkaa335.

Transcriptomics-based validation of the relatedness of heterogeneous nuclear ribonucleoproteins to chronic lymphocytic leukemia as potential biomarkers of the disease aggressiveness.基于转录组学验证异质性核糖核蛋白与慢性淋巴细胞白血病的相关性，作为该疾病侵袭性的潜在生物标志物。

Saudi Med J. 2019 Apr;40(4):328-338. doi: 10.15537/smj.2019.4.23380.

Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies.细胞穿透肽基抗癌疗法的最新进展。

Molecules. 2019 Mar 7;24(5):927. doi: 10.3390/molecules24050927.

A novel function of API5 (apoptosis inhibitor 5), TLR4-dependent activation of antigen presenting cells.凋亡抑制因子5（API5）的一种新功能：Toll样受体4（TLR4）依赖性激活抗原呈递细胞

Oncoimmunology. 2018 Aug 15;7(10):e1472187. doi: 10.1080/2162402X.2018.1472187. eCollection 2018.

API5 confers cancer stem cell-like properties through the FGF2-NANOG axis.API5通过FGF2-NANOG轴赋予癌症干细胞样特性。

Oncogenesis. 2017 Jan 16;6(1):e285. doi: 10.1038/oncsis.2016.87.

Nucleoprotein of influenza A virus negatively impacts antiapoptotic protein API5 to enhance E2F1-dependent apoptosis and virus replication.甲型流感病毒核蛋白对抗凋亡蛋白API5产生负面影响，以增强E2F1依赖性凋亡和病毒复制。

Cell Death Dis. 2015 Dec 17;6(12):e2018. doi: 10.1038/cddis.2015.360.

A nuclear odyssey: fibroblast growth factor-2 (FGF-2) as a regulator of nuclear homeostasis in the nervous system.一场核之旅：成纤维细胞生长因子-2（FGF-2）作为神经系统核稳态的调节因子

Cell Mol Life Sci. 2015 May;72(9):1651-62. doi: 10.1007/s00018-014-1818-6. Epub 2015 Jan 1.

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The antiapoptotic protein Api5 and its partner, high molecular weight FGF2, are up-regulated in B cell chronic lymphoid leukemia.

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