Ramharter Michael, Schuster Katharina, Bouyou-Akotet Marielle K, Adegnika Ayola A, Schmits Kristen, Mombo-Ngoma Ghyslain, Agnandji Selidji T, Nemeth Johannes, Afène Solange Nzenze, Issifou Saadou, Onnas Isabelle Ndombi, Kombila Maryvonne, Kremsner Peter G
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon.
Am J Trop Med Hyg. 2007 Sep;77(3):418-22.
Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine has recently been adopted by many African countries to reduce maternal and neonatal morbidity and mortality associated with malaria in pregnancy. We assessed the impact of a newly established national IPTp program on maternal and neonatal health in Gabon. Data on prevalence of maternal Plasmodium falciparum infection, anemia, premature birth, and birth weight were collected in cross-sectional surveys in urban and rural regions of Gabon before and after the implementation of IPTp in a total of 1403 women and their offspring. After introduction of IPTp, the prevalence of maternal Plasmodium falciparum infection decreased dramatically (risk ratio 0.16, P < 0.001). Whereas only a modest effect on the rate of anemia in pregnant women was observed, there was a marked benefit on the prevalence of low birth weight and premature birth for women adhering to national recommendations. These effects were most pronounced in primi- and secundigravid women.
许多非洲国家最近采用了用周效磺胺 - 乙胺嘧啶进行孕期间歇性预防治疗（IPTp），以降低与妊娠疟疾相关的孕产妇和新生儿发病率及死亡率。我们评估了加蓬一项新设立的全国IPTp项目对孕产妇和新生儿健康的影响。在加蓬城乡地区实施IPTp前后，通过横断面调查收集了总共1403名妇女及其后代的恶性疟原虫感染率、贫血、早产和出生体重的数据。引入IPTp后，孕产妇恶性疟原虫感染率大幅下降（风险比0.16，P < 0.001）。虽然对孕妇贫血率仅观察到适度影响，但对于遵守国家建议的妇女，低出生体重和早产的患病率有显著改善。这些影响在初产妇和经产妇中最为明显。
