Sch 213766，一种来自球毛壳菌的新型趋化因子受体CCR-5抑制剂。
Sch 213766, a novel chemokine receptor CCR-5 inhibitor from Chaetomium globosum.
作者信息
Yang Shu-Wei, Mierzwa Ronald, Terracciano Joseph, Patel Mahesh, Gullo Vincent, Wagner Nicole, Baroudy Bahige, Puar Mohindar, Chan Tze-Ming, Chu Min
机构信息
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA.
出版信息
J Antibiot (Tokyo). 2007 Aug;60(8):524-8. doi: 10.1038/ja.2007.67.
A novel fungal secondary metabolite, Sch 213766 was isolated from the fungal fermentation broth of Chaetomium globosum as the chemokine receptor CCR-5 inhibitor and shown to be the methyl ester of the previously described tetramic acid Sch 210972 on the basis of UV, MS and NMR spectral data analyses. Sch213766 exhibited an IC(50) value of 8.6 muM in the CCR-5 receptor in vitro binding assay.
一种新型真菌次级代谢产物Sch 213766从球毛壳菌的真菌发酵液中分离出来，作为趋化因子受体CCR - 5抑制剂。基于紫外、质谱和核磁共振光谱数据分析，它被证明是先前描述的四嗪酸Sch 210972的甲酯。在体外CCR -
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