具有早熟变态诱导活性的4-（2-芳氧基己氧基）苯甲酸乙酯的保幼激素活性
Juvenile hormone activity of ethyl 4-(2-aryloxyhexyloxy)benzoates with precocious metamorphosis-inducing activity.
作者信息
Fujita Norihiro, Ashibe Kiyo, Yamada Naotaka, Shiotsuki Takahiro, Kiuchi Makoto, Kuwano Eiichi
机构信息
Laboratory of Pesticide Chemistry, Department of Applied Genetics and Pest Management, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
出版信息
Biosci Biotechnol Biochem. 2007 Sep;71(9):2333-4. doi: 10.1271/bbb.70265. Epub 2007 Sep 7.
Ethyl 4-[2-(6-methyl-3-pyridyloxy)hexyloxy]benzoate (1) and ethyl 4-(2-phenoxyhexyloxy)benzoate (2), which induce precocious metamorphosis in larvae of Bombyx mori, a clear sign of juvenile hormone (JH) deficiency, showed JH activity when topically applied to allatectomized 4th instar larvae of B. mori. Compounds 1 and 2 induced precocious metamorphosis with doses at which they were effective as JH agonists.
4-[2-(6-甲基-3-吡啶氧基)己氧基]苯甲酸乙酯(1)和4-(2-苯氧基己氧基)苯甲酸乙酯(2)可诱导家蚕幼虫早熟变态，这是保幼激素(JH)缺乏的明显迹象，当将其局部施用于去腺体的家蚕四龄幼虫时，表现出保幼激素活性。化合物1和2在作为保幼激素激动剂有效的剂量下诱导早熟变态。
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