Belfort R, de Smet M, Whitcup S M, Pavesio C, Lottenberg C, Rubin B, Lopez J S, Nussenblatt R
Escola Paulista de Medicina, Hospital São Paulo-Brasil.
Cornea. 1991 Nov;10(6):536-8. doi: 10.1097/00003226-199111000-00013.
Recent reports suggest that acquired immunodeficiency syndrome (AIDS) patients are at higher risk of developing mucocutaneous reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome (SJS). Resultant dry eye may be further exacerbated by human immunodeficiency virus (HIV) related lacrimal gland dysfunction and lead to a chronic keratoconjunctivitis. We report one patient with AIDS and toxic epidermal necrolysis and two patients with AIDS and SJS who developed severe dry eye misdiagnosed as infectious keratoconjunctivitis. Cicatrizing mucocutaneous reactions should be suspected in AIDS patients and the dry eye treated to control symptoms and prevent complications.
近期报告表明，获得性免疫缺陷综合征（艾滋病）患者发生中毒性表皮坏死松解症和史蒂文斯-约翰逊综合征（SJS）等皮肤黏膜反应的风险更高。由人类免疫缺陷病毒（HIV）相关的泪腺功能障碍可能会使由此引发的干眼症进一步加重，进而导致慢性角结膜炎。我们报告了1例患有艾滋病和中毒性表皮坏死松解症的患者，以及2例患有艾滋病和SJS且发生严重干眼症并被误诊为感染性角结膜炎的患者。对于艾滋病患者，应怀疑有瘢痕性皮肤黏膜反应，并对干眼症进行治疗以控制症状并预防并发症。
