史蒂文斯-约翰逊综合征或中毒性表皮坏死松解症患儿的泪道冲洗：一项五年回顾性研究

Lacrimal passage irrigation in children with Stevens-Johnson syndrome or toxic epidermal necrolysis: a five-year retrospective study.

作者信息

Xiang Qin, Gao Xu, Fang Jing, Pi Lianhong, Chen Xinke, Chen Lin, Liu Qing

机构信息

Department of Ophthalmology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.

China International Science and Technology Cooperation basis of Child Development and Critical Disorders, Chongqing, China.

出版信息

BMC Ophthalmol. 2019 Jan 18;19(1):22. doi: 10.1186/s12886-018-1014-9.

DOI:10.1186/s12886-018-1014-9

PMID:30658599

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6339389/

Abstract

BACKGROUND

To identity the effect of lacrimal system irrigation in the acute stage in children with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

METHODS

A retrospective review of 39 patients with SJS or TEN from 2012 to 2017 was analyzed. Patients were divided into two subgroups according to whether they received irrigation in the acute stage. The irrigation group included 21 inpatients and the control group included 18 inpatients. The χ2 test was used to compare clinical findings and data in both groups.

RESULTS

The rate of lacrimal system obstructions in the chronic stage of SJS or TEN in the irrigation group was significantly lower than in the control group (p < 0.01). A significant difference was also found between the epiphora rates in patients with SJS or TEN in the chronic stage in the two groups (p = 0.047). One of 15 patients with mild dry eyes or without dry eyes in the irrigation group had epiphora, and it affected five of 12 in the control group. The difference between the two groups was significant (p = 0.03). Epiphora in the two patients in the control group was long-term, owing to the disappearance of puncta marks.

CONCLUSIONS

Lacrimal system irrigation with dexamethasone drops in the acute stage was a simple way to lessen lacrimal system obstructions and epiphora in patients with SJS or TEN. It should be considered a conventional ocular treatment for SJS or TEN.

摘要

背景

确定泪道系统冲洗在儿童史蒂文斯-约翰逊综合征（SJS）或中毒性表皮坏死松解症（TEN）急性期的作用。

方法

对2012年至2017年的39例SJS或TEN患者进行回顾性分析。根据患者在急性期是否接受冲洗将其分为两个亚组。冲洗组包括21例住院患者，对照组包括18例住院患者。采用χ2检验比较两组的临床表现和数据。

结果

冲洗组SJS或TEN慢性期泪道系统阻塞发生率显著低于对照组（p < 0.01）。两组SJS或TEN慢性期患者溢泪率也存在显著差异（p = 0.047）。冲洗组15例轻度干眼或无干眼患者中有1例发生溢泪，而对照组12例中有5例发生溢泪。两组差异有统计学意义（p = 0.03）。对照组2例患者因泪点痕迹消失导致长期溢泪。