Kikuchi Haruhisa
Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki Aoba, Sendai, Japan.
Yakugaku Zasshi. 2007 Sep;127(9):1431-9. doi: 10.1248/yakushi.127.1431.
Cellular slime molds are thought to be excellent model organisms for the study of cell and developmental biology because of their simple pattern of development. However, there have been few reports on secondary metabolites of them. We have focused on the utility of cellular slime molds as novel resources for natural product chemistry, and have studied the diversity of secondary metabolites produced by them as well as their physiological and pharmacological activities. We have recently isolated many novel compounds from the fruiting bodies of various species of Dictyostelium cellular slime molds. Total syntheses and biological evaluation of these compounds have been carried out. It was shown that dictyopyrones and dictyomedins may regulate Dictyostelium development. Amino sugar derivatives such as furanodictines and dictyoglucosamines induced neuronal differentiation of rat PC-12 cells. In addition, brefelamide inhibited the cellular proliferation of 1321N1 human astrocytoma cells. These results show that cellular slime molds are promising sources in natural product chemistry.
由于细胞黏菌具有简单的发育模式，它们被认为是研究细胞和发育生物学的优秀模式生物。然而，关于它们次生代谢产物的报道却很少。我们一直专注于细胞黏菌作为天然产物化学新资源的实用性，并研究了它们产生的次生代谢产物的多样性及其生理和药理活性。我们最近从各种盘基网柄菌属细胞黏菌的子实体中分离出了许多新化合物。已经对这些化合物进行了全合成和生物学评价。结果表明，盘基网柄菌素和盘基网柄菌甲素可能调节盘基网柄菌的发育。呋喃盘基网柄菌素和盘基网柄菌葡糖胺等氨基糖衍生物可诱导大鼠PC-12细胞的神经元分化。此外，布雷菲酰胺可抑制1321N1人星形细胞瘤细胞的细胞增殖。这些结果表明，细胞黏菌是天然产物化学中有前景的来源。
