Krustev A, Sirakov V, Turiiski V, Getova D, Velkova K, Prissadova N
Department of Biophysics, Medical University, Plovdiv, Bulgaria.
Pharmacology. 2008;81(1):50-6. doi: 10.1159/000107969. Epub 2007 Sep 7.
Most of the side effects induced by tacrine are associated with the gastrointestinal (GI) tract. The aim of the study was to analyze the nature of radiographically registered, tacrine-induced changes in evacuatory function, as well as to find a possible correlation with the immediate in vitro action of the drug on smooth muscles from the GI tracts of rats. The tacrine dose we used reliably delayed GI passage: contrast matter was not fully evacuated, predominantly from the stomach and cecum. The delay resulted from changes in tone and peristaltic activity, specific for the various regions of the tract. These changes were associated with a superposing of the responses due to the anticholinesterase and noncholinergic action of tacrine.
他克林引起的大多数副作用与胃肠道（GI）有关。本研究的目的是分析经放射学记录的他克林引起的排空功能变化的性质，并找出其与该药物对大鼠胃肠道平滑肌的直接体外作用之间的可能关联。我们使用的他克林剂量确实延迟了胃肠道的通过时间：造影剂没有完全排空，主要是从胃和盲肠。这种延迟是由胃肠道不同区域特有的张力和蠕动活动变化引起的。这些变化与他克林的抗胆碱酯酶和非胆碱能作用所引起的反应叠加有关。
