Charnaia M A, Klypa T V, Morozov Iu A, Shmerko N P, Gladysheva V G, Andriianova A A
Khirurgiia (Mosk). 2007(8):17-20.
Effects of different doses and lots of protamine sulfate on hemostasis system after cardiac operations with artificial circulation are analyzed. Overall 982 patients underwent cardiac operations with artificial circulation. Quality and purity of protamine may be the causes of side effects. Negative effect of high doses of protamine on hemostasis system is demonstrated. Thrombocyte dysfunction is the main cause of intensive postoperative bleeding after administration of protamine high doses.
分析不同剂量和批次的硫酸鱼精蛋白对人工循环心脏手术后止血系统的影响。共有982例患者接受了人工循环心脏手术。鱼精蛋白的质量和纯度可能是副作用的原因。已证实高剂量鱼精蛋白对止血系统有负面影响。血小板功能障碍是高剂量鱼精蛋白给药后术后大量出血的主要原因。
