健康与疾病中的神经肽Y Y2受体
Neuropeptide Y Y2 receptor in health and disease.
作者信息
Parker S L, Balasubramaniam A
机构信息
Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
出版信息
Br J Pharmacol. 2008 Feb;153(3):420-31. doi: 10.1038/sj.bjp.0707445. Epub 2007 Sep 10.
Abstract
We briefly survey the current knowledge and concepts regarding structure and function of the neuropeptide Y Y2 receptor and its agonists, especially as related to pharmacology of the receptor and its roles in pathological processes. Specific structural features are considered that could be responsible for the known compartmentalization and participation of the receptor in cell and tissue organization. This is further discussed in relation to changes of levels of the Y2 receptor in pathological conditions (especially in epilepsy and drug abuse), to endocytosis and recycling, and to participation in wound healing, retinopathy and angiogenesis. Properties of the receptor and of Y2 agonists are considered and reviewed in connection to the negative regulation of transmitter release, feeding, mood and social behavior. The possible involvement of the Y2 receptor in diabetes, carcinogenesis and bone formation is also reviewed.
摘要
我们简要概述了目前关于神经肽Y Y2受体及其激动剂的结构与功能的知识和概念，特别是与该受体药理学及其在病理过程中的作用相关的内容。我们考虑了可能导致该受体已知的区室化以及其在细胞和组织组织中参与情况的特定结构特征。这将结合病理状况（特别是癫痫和药物滥用）下Y2受体水平的变化、内吞作用和再循环，以及在伤口愈合、视网膜病变和血管生成中的参与情况进行进一步讨论。我们还结合递质释放、进食、情绪和社会行为的负调节，对该受体和Y2激动剂的特性进行了考量和综述。此外，还综述了Y2受体在糖尿病、致癌作用和骨形成中可能的参与情况。
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