Mathieu A, Cauli A, Vacca A, Mameli A, Passiu G, Porru G, Piga M, Ibba V, Mura V, Sanna S
Rheumatology Unit, University of Cagliari, Monserrato, Cagliari, Italy.
Reumatismo. 2007;59 Suppl 1:25-7. doi: 10.4081/reumatismo.2007.1s.25.
Psoriasis and psoriatic arthritis are linked diseases characterised by (distinct ?) immune-mediated pathogenetic mechanisms and by a genetic background interacting with environmental factors. Some candidate susceptibility genes have been studied extensively; they include HLA genes, genes within the HLA region and genes outside the HLA region; among them corneodesmosin and other genes of PSORS1 region, MICA and TNF-a polymorphisms. The main findings in the literature are discussed.
银屑病和银屑病关节炎是相关联的疾病，其特征在于（独特的？）免疫介导的致病机制以及与环境因素相互作用的遗传背景。一些候选易感基因已得到广泛研究；它们包括HLA基因、HLA区域内的基因以及HLA区域外的基因；其中有角质层桥粒蛋白和PSORS1区域的其他基因、MICA和TNF-α多态性。本文讨论了文献中的主要发现。
