Funasaka Tatsuyoshi, Raz Avraham
Tumor Progression and Metastasis Program, Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Cancer Metastasis Rev. 2007 Dec;26(3-4):725-35. doi: 10.1007/s10555-007-9086-7.
Autocrine motility factor (AMF) is a tumor-secreted cytokine and is abundant at tumor sites, where it may affect the process of tumor growth and metastasis. AMF is a multifunctional protein capable of affecting cell migration, invasion, proliferation, and survival, and possesses phosphoglucose isomerase activity and can catalyze the step in glycolysis and gluconeogenesis. Here, we review the role of AMF and tumor environment on malignant processes. The outcome of metastasis depends on multiple interactions between tumor cells and homeostatic mechanisms, therefore elucidation of the tumor/host interactions in the tumor microenvironment is essential in the development of new prevention and treatment strategies. Such knowledge might provide clues to develop new future therapeutic approaches for human cancers.
自分泌运动因子（AMF）是一种肿瘤分泌的细胞因子，在肿瘤部位含量丰富，可能影响肿瘤生长和转移过程。AMF是一种多功能蛋白，能够影响细胞迁移、侵袭、增殖和存活，具有磷酸葡萄糖异构酶活性，可催化糖酵解和糖异生过程中的步骤。在此，我们综述了AMF和肿瘤环境在恶性过程中的作用。转移的结果取决于肿瘤细胞与稳态机制之间的多种相互作用，因此阐明肿瘤微环境中的肿瘤/宿主相互作用对于开发新的预防和治疗策略至关重要。这些知识可能为开发未来针对人类癌症的新治疗方法提供线索。
