Einat H, Tian F, Belmaker R H, Frost J W
Department of Pharmacy Practice and Pharmaceutical Education, College of Pharmacy, University of Minnesota, Duluth, MN, USA.
J Neural Transm (Vienna). 2008;115(1):55-8. doi: 10.1007/s00702-007-0807-4. Epub 2007 Sep 10.
Lithium and valproate are the prototypic mood stabilizers and have diverse structures and targets. Both drugs influence inositol metabolism. Lithium inhibits IMPase and valproate inhibits MIP synthase. This study shows that MIP synthase inhibition does not replicate or augment the effects of lithium in the inositol sensitive pilocarpine-induced seizures model. This lack of effects may stem from the low contribution of de-novo synthesis to cellular inositol supply or to the inhibition of the de-novo synthesis by lithium itself.
锂盐和丙戊酸盐是典型的心境稳定剂，具有不同的结构和作用靶点。两种药物均影响肌醇代谢。锂盐抑制肌醇一磷酸酶（IMPase），丙戊酸盐抑制肌醇一磷酸合成酶（MIP synthase）。本研究表明，在对肌醇敏感的毛果芸香碱诱导的癫痫模型中，抑制肌醇一磷酸合成酶并不会重现或增强锂盐的作用。这种缺乏效应可能源于从头合成对细胞内肌醇供应的贡献较低，或者是由于锂盐本身对从头合成的抑制作用。
