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[子宫内膜增殖、增生及腺癌中的凝集素组织化学检测]

[Lectin histochemical assay in endometrial proliferation, hyperplasia and adenocarcinoma].

作者信息

Tang J W

机构信息

Dalian Medical College, Liaoning.

出版信息

Zhonghua Zhong Liu Za Zhi. 1991 Sep;13(5):350-2.

PMID:1782847
Abstract

The binding capacity of five lectins in endometrial proliferation, hyperplasia and adenocarcinoma was studied histochemically. The staining density of ConA and WGA bound to intercellular and basal portion, the positive reaction and the density of both agglutinins to luminal borders were increased with the proliferative degree of endometrial glandular cells from proliferation to neoplasm, with the most significant binding in adenocarcinoma. However, WGA and RCA binding to basal portion of malignant cells was weak, but stronger in the outer edge of tumor mass. The authors suggest that lectin binding capacity provides a new probe to judge the proliferative degree and malignant transformation of endometrial glandular cells.

摘要

采用组织化学方法研究了5种凝集素在子宫内膜增殖、增生及腺癌中的结合能力。伴刀豆球蛋白A(ConA)和小麦胚凝集素(WGA)与细胞间及基底部分的结合染色密度,以及两种凝集素与管腔边界的阳性反应及密度,均随着子宫内膜腺细胞从增殖到肿瘤的增殖程度增加而升高,在腺癌中结合最为显著。然而,WGA和蓖麻凝集素(RCA)与恶性细胞基底部分的结合较弱,但在肿瘤块外缘结合较强。作者认为,凝集素结合能力为判断子宫内膜腺细胞的增殖程度和恶性转化提供了一种新的检测手段。

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