• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Modulation of interleukin-15-induced suppression of human neutrophil apoptosis by TNFalpha.

作者信息

Liu Xiuping, Xiong Changyun, Li Chunhong, Yang Deguang

机构信息

College of Life Science and Technology, Huazhong Universty of Science and Technology, Wuhan 430074, China.

出版信息

J Huazhong Univ Sci Technolog Med Sci. 2007 Aug;27(4):354-7. doi: 10.1007/s11596-007-0402-9.

DOI:10.1007/s11596-007-0402-9
PMID:17828485
Abstract

Human interleukin-15 (IL-15) is a proinflammatory cytokine to suppress neutrophil apoptosis, which is a potential therapeutic agent. The modulatory effect of TNFalpha was investigated in IL-15-induced suppression of human neutrophil apoptosis. TNFalpha was shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course. Moreover, this reverse effect by TNFalpha might be associated with a reduction of the expression of the anti-apoptotic Bcl-Xl protein detected by Western blotting. It is concluded that TNFalpha can be used to modulate IL-15-induced suppression of neutrophil apoptosis within certain time course.

摘要

相似文献

1
Modulation of interleukin-15-induced suppression of human neutrophil apoptosis by TNFalpha.
J Huazhong Univ Sci Technolog Med Sci. 2007 Aug;27(4):354-7. doi: 10.1007/s11596-007-0402-9.
2
NF-κB activation fails to protect cells to TNFα-induced apoptosis in the absence of Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w.在缺乏Bcl-xL而非Mcl-1、Bcl-2或Bcl-w的情况下，NF-κB激活无法保护细胞免受TNFα诱导的凋亡。
Biochim Biophys Acta. 2013 May;1833(5):1085-95. doi: 10.1016/j.bbamcr.2013.01.014. Epub 2013 Jan 28.
3
Differential modulation of cell death proteins in human brain cells by tumor necrosis factor alpha and platelet activating factor.肿瘤坏死因子α和血小板活化因子对人脑细胞中细胞死亡蛋白的差异调节
J Neurosci Res. 1998 Nov 15;54(4):530-8. doi: 10.1002/(SICI)1097-4547(19981115)54:4<530::AID-JNR10>3.0.CO;2-1.
4
Dexamethasone protects organ of corti explants against tumor necrosis factor-alpha-induced loss of auditory hair cells and alters the expression levels of apoptosis-related genes.地塞米松可保护柯替氏器外植体免受肿瘤坏死因子-α诱导的听觉毛细胞损失，并改变凋亡相关基因的表达水平。
Neuroscience. 2008 Nov 19;157(2):405-13. doi: 10.1016/j.neuroscience.2008.09.012. Epub 2008 Sep 11.
5
Differential effects of the autophagy inhibitors 3-methyladenine and chloroquine on spontaneous and TNF-α-induced neutrophil apoptosis.自噬抑制剂 3-甲基腺嘌呤和氯喹对自发性和 TNF-α诱导的中性粒细胞凋亡的差异作用。
Apoptosis. 2012 Oct;17(10):1050-65. doi: 10.1007/s10495-012-0738-x.
6
Bcl-xL/Bax ratio is altered by IFNgamma in TNFalpha- but not in TRAIL-induced apoptosis in colon cancer cell line.在结肠癌细胞系中，γ干扰素可改变肿瘤坏死因子α诱导凋亡时的Bcl-xL/Bax比率，但对肿瘤坏死因子相关凋亡诱导配体诱导凋亡时的该比率无影响。
Biochim Biophys Acta. 2005 Aug 15;1745(1):101-10. doi: 10.1016/j.bbamcr.2004.12.005. Epub 2005 Jan 11.
7
Interleukin-8 delays spontaneous and tumor necrosis factor-alpha-mediated apoptosis of human neutrophils.白细胞介素-8可延缓人中性粒细胞的自发性凋亡以及肿瘤坏死因子-α介导的凋亡。
Kidney Int. 1998 Jan;53(1):84-91. doi: 10.1046/j.1523-1755.1998.00741.x.
8
Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins.乙醇摄入期间白细胞介素-6升高作为一种潜在的内源性保护细胞因子，抵抗乙醇诱导的肝脏细胞凋亡：与Bcl-2和Bcl-x(L)蛋白的诱导有关。
Oncogene. 2002 Jan 3;21(1):32-43. doi: 10.1038/sj.onc.1205016.
9
Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8.白细胞介素-15通过细胞内事件而非细胞外因子延迟人中性粒细胞凋亡：Mcl-1的作用以及半胱天冬酶-3和半胱天冬酶-8活性降低
J Leukoc Biol. 2004 May;75(5):893-900. doi: 10.1189/jlb.1103585. Epub 2004 Feb 24.
10
BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis.人中性粒细胞在延迟性和加速性凋亡过程中BCL-2家族的表达
J Leukoc Biol. 2001 Nov;70(5):783-92.

引用本文的文献

1
Expression of interleukin-15 and its receptor on the surface of stimulated human umbilical vein endothelial cells.
J Huazhong Univ Sci Technolog Med Sci. 2009 Oct;29(5):527-34. doi: 10.1007/s11596-009-0501-x. Epub 2009 Oct 11.

本文引用的文献

1
Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8.白细胞介素-15通过细胞内事件而非细胞外因子延迟人中性粒细胞凋亡：Mcl-1的作用以及半胱天冬酶-3和半胱天冬酶-8活性降低
J Leukoc Biol. 2004 May;75(5):893-900. doi: 10.1189/jlb.1103585. Epub 2004 Feb 24.
2
Mechanisms involved in interleukin-15-induced suppression of human neutrophil apoptosis: role of the anti-apoptotic Mcl-1 protein and several kinases including Janus kinase-2, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2.白细胞介素-15诱导人中性粒细胞凋亡抑制的相关机制：抗凋亡蛋白Mcl-1以及包括Janus激酶-2、p38丝裂原活化蛋白激酶和细胞外信号调节激酶-1/2在内的多种激酶的作用
FEBS Lett. 2002 Dec 4;532(1-2):164-70. doi: 10.1016/s0014-5793(02)03668-2.
3
Interleukin-15 and the regulation of lymphoid homeostasis.
Mol Immunol. 2002 Dec;39(9):537-44. doi: 10.1016/s0161-5890(02)00211-0.
4
Modulation of interleukin-15-induced human neutrophil responses by the plant lectin Viscum album agglutinin-I.植物凝集素欧洲白蜡树凝集素-I对白细胞介素-15诱导的人中性粒细胞反应的调节作用
Clin Immunol. 2001 Nov;101(2):229-36. doi: 10.1006/clim.2001.5105.
5
Interleukin-15 and its impact on neutrophil function.白细胞介素-15及其对中性粒细胞功能的影响。
Curr Opin Hematol. 2000 May;7(3):174-7. doi: 10.1097/00062752-200005000-00008.
6
Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration.淋巴细胞功能相关抗原-1（LFA-1）和巨噬细胞-1抗原（Mac-1）对中性粒细胞黏附和迁移的相对贡献。
J Immunol. 1999 Nov 1;163(9):5029-38.
7
Bcl-Xl- and Bax-alpha-mediated regulation of apoptosis of human neutrophils via caspase-3.Bcl-Xl和Bax-α通过半胱天冬酶-3介导对人中性粒细胞凋亡的调控。
Blood. 1999 May 1;93(9):3106-15.
8
Natural killer cell differentiation: insights from knockout and transgenic mouse models and in vitro systems.自然杀伤细胞分化：来自基因敲除和转基因小鼠模型及体外系统的见解。
Immunol Rev. 1998 Oct;165:47-61. doi: 10.1111/j.1600-065x.1998.tb01229.x.
9
A comparative study of different methods for the assessment of apoptosis and necrosis in human eosinophils.评估人类嗜酸性粒细胞凋亡和坏死的不同方法的比较研究。
J Immunol Methods. 1998 Aug 1;217(1-2):153-63. doi: 10.1016/s0022-1759(98)00103-3.
10
Interleukin-15 and its role in chronic inflammatory diseases.白细胞介素-15及其在慢性炎症性疾病中的作用。
Inflamm Res. 1998 Jul;47(7):285-9. doi: 10.1007/s000110050331.