Naeim F, Forsberg M I, Waisman J, Coulson W F
Arch Pathol Lab Med. 1976 May;100(5):271-5.
In 112 patients with mixed tumors of the salivary glands, 94 tumors were located in parotid glands, 11 in submandibular salivary glands, and 7 in monor palatal salivary glands. Capsular ingrowth, a characteristic growth pattern, may explain the frequency of multilobulation and capsular defects in these tumors, particularly those of long standing. The capsular thickness, the extent of fibrosis with stromal hyalinization, and the degree of lymphocytic infiltration within and around the capsule, were associated with cellularity of the tumors. Thus, 69% of the hypocellular neoplasms had incomplete capsules, and only 13% showed moderate to substantial lymphocytic infiltration; corresponding figures for hypercellular tumors were 22% and 42%, respectively. Of the recurrent lesions, 61% were hypocellular; 11% of the hypercellular tumors recurred. Incomplete resection, hypocellularity, and incomplete encapsulation were considered to be the major factors in recurrence.
在112例涎腺混合瘤患者中，94例肿瘤位于腮腺，11例位于下颌下腺，7例位于腭部小涎腺。包膜内生长是一种特征性生长模式，这可能解释了这些肿瘤（尤其是病程较长者）多叶状及包膜缺损的发生率。包膜厚度、伴有基质玻璃样变的纤维化程度以及包膜内和包膜周围的淋巴细胞浸润程度，均与肿瘤的细胞密度相关。因此，69%的低细胞性肿瘤包膜不完整，仅有13%表现为中度至大量淋巴细胞浸润；高细胞性肿瘤的相应比例分别为22%和42%。在复发病变中，61%为低细胞性；高细胞性肿瘤的复发率为11%。不完全切除、低细胞性和包膜不完整被认为是复发的主要因素。
