Lesch K P, Aulakh C S, Tolliver T J, Hill J L, Murphy D L
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.
Eur J Pharmacol. 1991 Aug 14;207(4):361-4. doi: 10.1016/0922-4106(91)90012-7.
The effect of long-term (3-week) administration of various antidepressant drugs on the steady-state concentrations of G protein alpha subunits, Gs alpha, Gi alpha, and Go alpha, has been investigated in rat brain using an enzyme-linked immunosorbent assay. Tricyclic antidepressants and clorgyline decreased Gs alpha and, to a lesser extent, Gi alpha in several brain regions, while Go alpha was increased by tricyclics but not clorgyline. We conclude that long-term treatment with antidepressant drugs exerts differential effects on G protein alpha subunits, and that antidepressant efficacy may potentially be based on functional modifications of signal transduction.
利用酶联免疫吸附测定法，在大鼠脑中研究了长期（3周）给予各种抗抑郁药物对G蛋白α亚基（Gsα、Giα和Goα）稳态浓度的影响。三环类抗抑郁药和氯吉兰减少了几个脑区的Gsα，在较小程度上也减少了Giα，而三环类药物使Goα增加，但氯吉兰没有此作用。我们得出结论，长期使用抗抑郁药物对G蛋白α亚基有不同影响，且抗抑郁疗效可能潜在地基于信号转导的功能改变。
