Berenbaum M, Feeny P
Science. 1981 May 22;212(4497):927-9. doi: 10.1126/science.212.4497.927.
Xanthotoxin, a linear furanocoumarin occurring in many plants of the family Umbelliferae, is not appreciably toxic to the umbellifer-feeding larvae of Papilio polyxenes (Lepidoptera; Papilionidae), whereas angelicin, an angular furanocoumarin found only in a few relatively advanced tribes of the Umbelliferae, reduces growth rate and fecundity. The biosynthetic pathway leading to angular attachment of the furan ring may thus have been a response within the Umbelliferae to selective pressures exerted by specialized herbivores that had adapted to feeding on linear furanocoumarins.
黄樟毒素是一种存在于许多伞形科植物中的线性呋喃香豆素，对金凤蝶（鳞翅目；凤蝶科）以伞形科植物为食的幼虫没有明显毒性，而当归素是一种仅在少数相对进化的伞形科植物族中发现的角型呋喃香豆素，它会降低幼虫的生长速度和繁殖力。因此，导致呋喃环角型连接的生物合成途径可能是伞形科植物对已适应取食线性呋喃香豆素的特化食草动物所施加的选择压力的一种反应。
