Wölfle G, Bleyer H, Müller D, Klinger W
Ernst Moritz Arndt University Greifswald, Germany.
Exp Pathol. 1991;43(1-2):89-95. doi: 10.1016/s0232-1513(11)80152-0.
Cytochrome P-450 concentration and the monooxygenation activities of some cytochrome P-450 forms were determined in rat liver in the course of the acute radiation sickness. Ethylmorphine N-demethylation, ethoxycoumarin, ethoxyresorufin, and pentoxyresorufin O-dealkylation were used as indicator reactions. After radiation a distinct decrease in the hepatic biotransformation capacity can be observed, most pronounced at the climax of the radiation syndrome. Phenobarbital treatment (60 mg/kg b. m. at 3 consecutive days each) increases the concentration and the monooxygenase activities of some cytochrome P-450 forms. The degree of this induction effect is not altered at the third day after radiation, whereas at day 7 no significant inducibility can be observed.
在急性放射病病程中，测定了大鼠肝脏中细胞色素P - 450的浓度以及某些细胞色素P - 450形式的单加氧酶活性。以N - 脱乙基吗啡、乙氧香豆素、乙氧试卤灵和戊氧试卤灵的O - 脱烷基反应作为指示反应。辐射后可观察到肝脏生物转化能力明显下降，在放射综合征高峰期最为显著。苯巴比妥治疗（连续3天，每天60 mg/kg体重）可增加某些细胞色素P - 450形式的浓度和单加氧酶活性。这种诱导作用的程度在辐射后第3天没有改变，而在第7天则未观察到明显的诱导性。
