O'Keeffe S, Gzel A, Drury R, Cullina M, Greally J, Finnegan P
Dept of Respiratory Medicine, University College Hospital, Galway, Ireland.
Eur Respir J. 1991 Sep;4(8):932-6.
Immunoglobulin G (IgG) subclass levels were measured in 58 patients with chronic obstructive pulmonary disease (COPD) and in 125 healthy controls. Total IgG values were significantly lower in the 27 COPD patients on steroid therapy compared with patients not taking steroids (8.31 (0.14) vs 9.80 (0.14), p less than 0.05), geometric mean (log SD). Total IgG (9.80 (0.14) vs 12.18 (0.16), p less than 0.005), IgG1 (5.87 (0.19) vs 6.68 (0.12), p less than 0.05) and IgG2 levels (2.75 (0.21) vs 3.70 (0.20), p less than 0.005) were significantly reduced in the COPD patients not taking steroids compared with the controls. IgG3 values were significantly elevated in smokers compared with nonsmokers in both the control and COPD groups. Fifteen COPD patients (25.9%) had a low level of one or more subclasses. IgG2 subclass deficiency was the most common, being present in 9 patients. A significant correlation was found between forced expiratory volume in one second (FEV1) and IgG2 subclass levels (r = 0.415; p less than 0.005). IgG subclass deficiencies may contribute to the development and progression of respiratory disease in COPD patients.
对58例慢性阻塞性肺疾病（COPD）患者和125名健康对照者测定了免疫球蛋白G（IgG）亚类水平。与未服用类固醇的患者相比，27例接受类固醇治疗的COPD患者的总IgG值显著降低（几何均值（对数标准差）：8.31（0.14）对9.80（0.14），p<0.05）。未服用类固醇的COPD患者的总IgG（9.80（0.14）对12.18（0.16），p<0.005）、IgG1（5.87（0.19）对6.68（0.12），p<0.05）和IgG2水平（2.75（0.21）对3.70（0.20），p<0.005）与对照组相比显著降低。在对照组和COPD组中，吸烟者的IgG3值均显著高于非吸烟者。15例COPD患者（25.9%）有一种或多种亚类水平较低。IgG2亚类缺乏最为常见，有9例患者存在。发现一秒用力呼气量（FEV1）与IgG2亚类水平之间存在显著相关性（r = 0.415；p<0.005）。IgG亚类缺乏可能有助于COPD患者呼吸系统疾病的发生和发展。
