Björkander J, Bake B, Oxelius V A, Hanson L A
N Engl J Med. 1985 Sep 19;313(12):720-4. doi: 10.1056/NEJM198509193131203.
We examined the relation between serum levels of IgG subclasses and lung function, as determined by spirometry, lung volumes, the single-breath nitrogen test, and static recoil pressures, in 29 patients with IgA deficiency and repeated upper or lower respiratory tract infections. Four of the patients had decreased levels of IgG2, and two had decreased levels of IgG3. Two or more lung-function values were abnormal in each of these six patients and also in three others with normal levels of IgG subclasses. Low levels of IgG2 and IgG3 were significantly related to abnormal lung function (P less than 0.01). The 20 patients with normal lung function all had IgG-subclass levels above the lower range. There may be a causal relation between low levels of IgG subclasses and deterioration in lung function, suggesting that patients with combined IgA and IgG-subclass deficiencies may benefit from immunoglobulin prophylaxis.
我们对29例患有IgA缺乏症且反复出现上呼吸道或下呼吸道感染的患者，检测了血清IgG亚类水平与肺功能之间的关系，肺功能通过肺活量测定、肺容积、单次呼吸氮试验和静态回缩压来确定。其中4例患者的IgG2水平降低，2例患者的IgG3水平降低。这6例患者以及另外3例IgG亚类水平正常的患者中，均有两项或更多项肺功能值异常。IgG2和IgG3水平低与肺功能异常显著相关（P小于0.01）。20例肺功能正常的患者其IgG亚类水平均高于较低范围。IgG亚类水平低与肺功能恶化之间可能存在因果关系，这表明合并有IgA和IgG亚类缺乏的患者可能会从免疫球蛋白预防中获益。
