Science. 1962 Nov 2;138(3540):593-4. doi: 10.1126/science.138.3540.593.
In 139 families having a child born with anencephalus or spina bifida, 10 of 308 siblings of the affected children had malformations similar to those of the affected children. The incidence of these malformations in siblings of affected children is significantly greater than the incidence in the general population.
在 139 个有孩子出生时患有无脑畸形或脊柱裂的家庭中，受影响孩子的 308 个兄弟姐妹中有 10 个有类似受影响孩子的畸形。受影响孩子的兄弟姐妹中这些畸形的发生率明显高于一般人群的发生率。
