甾醇14α-去甲基酶及其抑制作用：唑类抗真菌剂与酵母羊毛甾醇14α-去甲基酶（P-450(14DM)）相互作用的结构考量 - Suppr

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超能文献

Sterol 14 alpha-demethylase and its inhibition: structural considerations on interaction of azole antifungal agents with lanosterol 14 alpha-demethylase (P-450(14DM)) of yeast.

作者信息

Yoshida Y, Aoyama Y

机构信息

Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.

出版信息

Biochem Soc Trans. 1991 Aug;19(3):778-82. doi: 10.1042/bst0190778.

DOI:10.1042/bst0190778

PMID:1783215

Abstract

摘要

相似文献

Sterol 14 alpha-demethylase and its inhibition: structural considerations on interaction of azole antifungal agents with lanosterol 14 alpha-demethylase (P-450(14DM)) of yeast.甾醇14α-去甲基酶及其抑制作用：唑类抗真菌剂与酵母羊毛甾醇14α-去甲基酶（P-450(14DM)）相互作用的结构考量

Biochem Soc Trans. 1991 Aug;19(3):778-82. doi: 10.1042/bst0190778.

Molecular modelling of lanosterol 14 alpha-demethylase (CYP51) from Saccharomyces cerevisiae via homology with CYP102, a unique bacterial cytochrome P450 isoform: quantitative structure-activity relationships (QSARs) within two related series of antifungal azole derivatives.通过与独特的细菌细胞色素P450同工型CYP102同源性对酿酒酵母羊毛甾醇14α-去甲基酶（CYP51）进行分子建模：两个相关系列抗真菌唑衍生物的定量构效关系（QSARs）

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Cytochrome P-450-dependent 14 alpha-sterol demethylase of Candida albicans and its interaction with azole antifungals.白色念珠菌的细胞色素P-450依赖性14α-甾醇脱甲基酶及其与唑类抗真菌药的相互作用。

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Inhibition by a novel azole antifungal agent with a geranyl group on lanosterol 14 alpha-demethylase of yeast.一种带有香叶基的新型唑类抗真菌剂对酵母羊毛甾醇14α-去甲基酶的抑制作用。

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Differential inhibition of human CYP3A4 and Candida albicans CYP51 with azole antifungal agents.唑类抗真菌剂对人细胞色素P450 3A4（CYP3A4）和白色念珠菌细胞色素P450 51（CYP51）的差异性抑制作用。

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Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida albicans.唑类抗真菌抗生素与从白色念珠菌中纯化的细胞色素P-450依赖性14α-甾醇脱甲基酶的相互作用。

Biochem J. 1990 Mar 1;266(2):475-80. doi: 10.1042/bj2660475.

Multiple amino acid substitutions in lanosterol 14alpha-demethylase contribute to azole resistance in Candida albicans.羊毛甾醇14α-去甲基酶中的多个氨基酸取代导致白色念珠菌对唑类药物产生耐药性。

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Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus.利用在同源位点对甾醇14α-脱甲基酶进行人源化改造的酿酒酵母菌株，对比不同唑类抗真菌药的疗效。

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Interaction of azole antifungal agents with cytochrome P-45014DM purified from Saccharomyces cerevisiae microsomes.唑类抗真菌剂与从酿酒酵母微粒体中纯化的细胞色素P - 45014DM的相互作用。

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Non-sterol structural probes of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae.来自酿酒酵母的羊毛甾醇14α-脱甲基酶的非甾醇结构探针。

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