Science. 1946 Mar 29;103(2674):398-9. doi: 10.1126/science.103.2674.398.
Like pantothenic acid, pantolactone, and the pantoate ion, pantoyltaurine and other pantothenic acid analogues of this type antagonize the inhibitory effect of salicylate on E. coli. It is suggested that the active antagonist in a solution of such an analogue is pantolactone or pantoate. These (particularly the former) could conceivably be contaminants of the analogues. However, the liberation of pantoate by hydrolysis, appears to be a more likely explanation for the antisalicylate effect. The presence of pantolactone or pantoate in a solution of pantoyltaurine and similar analogues of pantothenic acid provides a possible explanation for the ineffectiveness of these drugs in inhibiting the growth of microorganisms which can utilize pantolactone or pantoate for the synthesis of pantothenic acid.
与泛酸、泛醇和 pantoate 离子一样，泛酰巯基乙胺和这类泛酸的其他类似物能够拮抗水杨酸盐对大肠杆菌的抑制作用。这表明，此类类似物溶液中的活性拮抗剂是泛醇或 pantoate。这些（特别是前者）很可能是类似物的污染物。然而，pantoate 通过水解释放，似乎更有可能解释抗水杨酸盐的作用。在泛酰巯基乙胺和泛酸的类似物溶液中存在泛醇或 pantoate，为这些药物抑制能够利用泛醇或 pantoate 合成泛酸的微生物的生长无效提供了一种可能的解释。
