6-O-酰化胞壁酰二肽中异谷氨酰胺残基的甲酯化对免疫药理活性表达的影响。

Effect of methyl esterification of isoglutamine residue in 6-O-acylated muramyl dipeptides on expression of immunopharmacological activities.

作者信息

Furuya T, Kumazawa Y, Takimoto H, Nagumo T, Kiso M, Hasegawa A, Nomoto K

机构信息

School of Hygeinic Sciences, Kitasato University, Sagamihara, Japan.

出版信息

Int J Immunopharmacol. 1991;13(5):573-7. doi: 10.1016/0192-0561(91)90078-l.

DOI:10.1016/0192-0561(91)90078-l

PMID:1783471

Abstract

The effect of methyl esterification of the isoglutamine residue in 6-O-acylated muramyl dipeptide (MDP) on some biological activities was investigated. Methyl esterification influenced more or less the expression of all activities tested. The adjuvant and colony stimulating factor (CSF)-inducing activities of 6-O-acylated MDP analogs carrying a 3-hexadecanoyloxytetradecanoyl [C14-O-(C16)] group were stronger than those of the corresponding analogs carrying a 2-tetradecylhexadecanoyl (B30) group. Macrophage activation, i.e. induction of tumor necrosis factor (TNF) and promotion of phagocytosis, by 6-O-C14-O-(C16)-MDP methyl esters was weaker.

摘要

研究了6-O-酰化胞壁酰二肽（MDP）中异谷氨酰胺残基的甲酯化对某些生物学活性的影响。甲酯化或多或少影响了所有测试活性的表达。带有3-十六烷酰氧基十四烷酰基[C14-O-(C16)]基团的6-O-酰化MDP类似物的佐剂和集落刺激因子（CSF）诱导活性比带有2-十四烷基十六烷酰基（B30）基团的相应类似物更强。6-O-C14-O-(C16)-MDP甲酯对巨噬细胞的激活作用，即肿瘤坏死因子（TNF）的诱导和吞噬作用的促进作用较弱。