Science. 1965 Jul 16;149(3681):323-5. doi: 10.1126/science.149.3681.323.
Clinical reports of alleviation of pain with positive brain stimulation were investigated experimnentally. Rats in a two-compartment testing chamber sought out hypothalamic stimulation and escaped from aversive foot shock delivered through a grid-scrambling device. Animals also sought out paired hypothalamic stimulation and foot shock. Control experiments demonstrating that animals did not discriminate between hypothalamic stimulcation and paired hypothalamic stimulation and foot shock supported the view that hypothalamic stimulation attenuates the aversive properties of foot shock.
临床报告显示，正性脑刺激可缓解疼痛。实验中，大鼠在双室测试室中寻求下丘脑刺激，并通过网格扰乱装置逃避令人厌恶的足底电击。动物也寻求配对的下丘脑刺激和足底电击。控制实验证明，动物不能区分下丘脑刺激和配对的下丘脑刺激与足底电击，这支持了下丘脑刺激减轻足底电击的厌恶特性的观点。
