Ishitobi F, Sagiya A, Ueda Y, Oka K, Kanaya H, Iidaka K
Department of Pathology, Dokkyo University School of Medicine, Tochigi, Japan.
J Pathol. 1991 Dec;165(4):329-36. doi: 10.1002/path.1711650409.
A morphometric analysis was performed to compare the capillary area in non-sclerotic glomeruli in focal glomerular sclerosis (FGS), pre-eclampsia with focal sclerotic change of the glomeruli, and minimal change nephrotic syndrome (MCNS). The mean and standard deviation of the capillary area was greater in FGS than in pre-eclampsia and MCNS. Tubulo-interstitial lesions, such as tubular atrophy, interstitial fibrosis, and lymphocytic infiltration, were more severe in FGS than in pre-eclampsia. The presence of tubulo-interstitial changes including tubular atrophy and interstitial fibrosis with lymphocytic infiltration is thought to be an important prognostic factor in pre-eclampsia as well as in FGS. Unequal dilatation of the glomerular capillaries in non-sclerotic glomeruli may be harmful to the glomeruli and may lead to the development of glomerular sclerosis.
进行了形态计量分析，以比较局灶性肾小球硬化（FGS）、伴有肾小球局灶性硬化改变的先兆子痫和微小病变肾病综合征（MCNS）中非硬化性肾小球的毛细血管面积。FGS中毛细血管面积的平均值和标准差高于先兆子痫和MCNS。FGS中的肾小管间质病变，如肾小管萎缩、间质纤维化和淋巴细胞浸润，比先兆子痫更严重。包括肾小管萎缩、间质纤维化伴淋巴细胞浸润在内的肾小管间质变化的存在，被认为是先兆子痫和FGS中一个重要的预后因素。非硬化性肾小球中肾小球毛细血管的不等扩张可能对肾小球有害，并可能导致肾小球硬化的发展。
