Nochy D, Hinglais N, Jacquot C, Gaudry C, Remy P, Bariety J
Clin Nephrol. 1986 Mar;25(3):116-21.
Eleven women were selected on the presence, in postpartum renal biopsies, of focal glomerulosclerosis (FGS) superimposed to glomerular lesions of typical pregnancy-induced nephropathy. Ten out of them presented with severe preeclampsia. The renal specimens were examined by light and/or electron and/or immunofluorescence microscopy. The present study gathered clinical and morphological data suggesting that FGS might develop during preeclampsia. In these renal biopsies with FGS and lesions of pregnancy-induced nephropathy a sparse detachment of podocyte was observed at a distance from the segmental lesions by electron microscopy. The latter has also been observed in experimental models of FGS in which FGS is dependent on glomerular hemodynamic alterations. We think that the mechanism of the development of FGS in these pathological pregnancies may be analogous to these experimental models of FGS with hyperfiltration.
选取了11名女性，她们产后肾活检显示局灶性肾小球硬化（FGS）叠加于典型妊娠诱发肾病的肾小球病变之上。其中10名患有重度子痫前期。通过光学显微镜、电子显微镜和/或免疫荧光显微镜对肾脏标本进行检查。本研究收集的临床和形态学数据表明，FGS可能在子痫前期发生。在这些伴有FGS和妊娠诱发肾病病变的肾活检中，通过电子显微镜观察到足细胞在距节段性病变一定距离处有稀疏脱离。在FGS依赖于肾小球血流动力学改变的FGS实验模型中也观察到了后者。我们认为，这些病理性妊娠中FGS的发生机制可能类似于这些伴有超滤的FGS实验模型。
