Sato H, Narita A, Matsumoto K, Nakazawa S, Suzuki H, Nakanishi Y, Nagao K, Nakazawa S, Niinou K
Department of Pediatrics, Tokyo Metropolitan Ebara General Hospital.
Jpn J Antibiot. 1991 Nov;44(11):1250-8.
Studies on pharmacokinetics and clinical effects of flomoxef (FMOX), a parenteral oxacephem antibiotic, were carried out in neonates. The results obtained are summarized as follows. 1. Mean peak serum concentrations of FMOX upon single administrations at doses of 20 mg/kg and 40 mg/kg were 33.3 +/- 7.33 micrograms/ml and 68.9 micrograms/ml, respectively. 2. Mean urinary recovery rates of FMOX in the first 6 hours after administration of the above doses were 35.2% and 48.3%, respectively. 3. FMOX was administered to 4 cases including 1 prophylactic case, 1 case each with aspiration pneumonia and sepsis, hypodermic abscess of the head, and itrauterine infection, at a dose of 20-30 mg/kg 2 or 3 times a day. Clinically, excellent results were obtained in 3 cases including an methicillin-resistant Staphylococcus aureus case. 4. No side effects nor abnormal laboratory test results were observed.
对非肠道用氧头孢烯类抗生素氟氧头孢（FMOX）在新生儿中的药代动力学和临床效果进行了研究。获得的结果总结如下。1. 单次给予20mg/kg和40mg/kg剂量的FMOX后，血清平均峰浓度分别为33.3±7.33μg/ml和68.9μg/ml。2. 给予上述剂量后，前6小时FMOX的平均尿回收率分别为35.2%和48.3%。3. 对4例患者使用FMOX，包括1例预防性用药患者、1例吸入性肺炎患者、1例败血症患者、1例头部皮下脓肿患者和1例宫内感染患者，剂量为20 - 30mg/kg，每日2或3次。临床上，3例患者取得了良好效果，其中包括1例耐甲氧西林金黄色葡萄球菌感染患者。4. 未观察到副作用或实验室检查结果异常。
