Akita H, Sato Y, Iwata S, Sunakawa K, Yokota T
Department of Pediatrics, Yamato City Hospital.
Jpn J Antibiot. 1991 Nov;44(11):1240-9.
Studies were made on pharmacokinetics, clinical effects and influence on intestinal bacterial flora in neonates upon administration of flomoxef (FMOX), and the results obtained are summarized as follows: 1. Serum concentrations of FMOX after intravenous administration of 20 mg/kg/dose were 48.5 micrograms/ml in 30 minutes, 33.0 micrograms/ml in 1 hour and 7.3 micrograms/ml in 6 hours. The T 1/2 was 2.7 hours. FMOX at a dose of 40 mg/kg was given to only one new born baby on the 1st day after birth, and serum concentrations were 73.6 micrograms/ml in 30 minutes, 55.9 micrograms/ml in 1 hour and 16.9 micrograms/ml in 6 hours. The T 1/2 was 4.60 hours. 2. FMOX was administered to 21 neonates between 0 and 32 days of age. Clinical effects were evaluable in 8 of 21 cases. The results were excellent in 2 cases, good in 5 cases and poor in 1 case. Of the 21 cases, diarrhea in 1 case, elevation of eosinophile in 2 cases (9.5%), elevation of platelet count in 3 cases (14.3%), and elevation of GOT in 2 cases (9.5%) were recognized during treatment. 3. FMOX was detected in feces at levels of 0.84-44.4 micrograms/g. Except for a slight decrease in numbers of anaerobes, little fluctuations of intestinal flora were observed during treatment.
对新生儿使用氟氧头孢（FMOX）后的药代动力学、临床效果及对肠道菌群的影响进行了研究，结果总结如下：1. 静脉注射20mg/kg/剂量后，30分钟时FMOX血清浓度为48.5微克/毫升，1小时时为33.0微克/毫升，6小时时为7.3微克/毫升。半衰期为2.7小时。仅对1例出生第1天的新生儿给予40mg/kg的剂量，30分钟时血清浓度为73.6微克/毫升，1小时时为55.9微克/毫升，6小时时为16.9微克/毫升。半衰期为4.60小时。2. 对21例0至32日龄的新生儿给予FMOX。21例中有8例可评估临床效果。结果为优2例，良5例，差1例。21例中，治疗期间有1例出现腹泻，2例（9.5%）嗜酸性粒细胞升高，3例（14.3%）血小板计数升高，2例（9.5%）谷草转氨酶升高。3. 在粪便中检测到FMOX的水平为0.84 - 44.4微克/克。除厌氧菌数量略有减少外，治疗期间肠道菌群几乎没有波动。
