Civiale C, Ritschel W A, Shiu G K, Aiache J M, Beyssac E
Biopharmaceutics Department, Faculty of Pharmacy, Clermont-Ferrand, France.
Methods Find Exp Clin Pharmacol. 1991 Sep;13(7):491-8.
The drug release of salbutamol from a controlled release (osmotic pump) tablet was determined in vitro by four different dissolution apparatuses. From published in vivo data, percent of drug absorbed and percent of drug released in vivo were estimated. The highest correlation was obtained between percentage released in vitro versus percentage released in vivo using polynomial regression.
通过四种不同的溶出装置在体外测定了沙丁胺醇从控释（渗透泵）片剂中的药物释放情况。根据已发表的体内数据，估算了药物的吸收百分比和体内释放百分比。使用多项式回归，体外释放百分比与体内释放百分比之间获得了最高的相关性。
