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内布拉斯加州的先天性梅毒:一例病例报告。

Congenital syphilis in Nebraska: a case report.

作者信息

Frecentese D F, Schreiman J S

机构信息

Department of Radiology, Creighton University School of Medicine, Omaha, Nebraska 68131.

出版信息

Nebr Med J. 1991 Oct;76(10):330-4.

PMID:1784314
Abstract

In the United States, the incidence of acquired syphilis has increased thirty four percent in the last decade with young, black, urban dwelling, drug dependent females representing the highest risk group. Concomitantly, congenital syphilis has increased causing spontaneous abortions, stillbirths, and neonatal morbidity and longterm neurologic sequela. Because physicians are no longer familiar with the disease, it is estimated that only twenty-five percent of neonatal syphilis is diagnosed during the first year of life. This report describes the first reported case of congenital syphilis in Nebraska. Our patient demonstrates the typical clinical findings of lethargy, extremity swelling and the pseudoparalysis of Parot, while laboratory evaluation showed anemia, abnormal hepatic enzymes, hypoproteinemia, and confirmatory positive neonatal VDRL and FTA-ABS. The plain film radiographic survey illustrated the characteristic findings of periostitis, metaphyseal banding and cortical erosion. By relying upon the relatively inexpensive and easy to obtain radiographic long bone survey a prompt diagnosis can be made and immediate treatment instituted while awaiting confirmatory serology. We must reacquaint ourselves with the increasing incidence of acquired and congenital syphilis. This will enable us to make a timely and cost-effective diagnosis of cogenital syphilis and prevent its devastating complications.

摘要

在美国,过去十年间获得性梅毒的发病率上升了34%,年轻、黑人、居住在城市、依赖毒品的女性是风险最高的群体。与此同时,先天性梅毒有所增加,导致自然流产、死产、新生儿发病以及长期神经后遗症。由于医生对这种疾病不再熟悉,据估计,只有25%的新生儿梅毒在出生后第一年内得到诊断。本报告描述了内布拉斯加州首例先天性梅毒报告病例。我们的患者表现出嗜睡、肢体肿胀和帕罗假瘫等典型临床症状,而实验室检查显示贫血、肝酶异常、低蛋白血症,新生儿VDRL和FTA-ABS确诊呈阳性。X线平片检查显示了骨膜炎、干骺端带状影和皮质侵蚀的特征性表现。通过依靠相对廉价且易于获得的长骨X线检查,可以在等待确诊血清学检查结果的同时迅速做出诊断并立即进行治疗。我们必须重新熟悉获得性和先天性梅毒发病率的上升情况。这将使我们能够及时且经济高效地诊断先天性梅毒,并预防其毁灭性的并发症。

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