生物蝶呤与叶酸之间的一些代谢关系：对“甲基陷阱假说”的影响
Some metabolic relationships between biopterin and folate: implications for the "methyl trap hypothesis".
作者信息
Kaufman S
机构信息
Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, Maryland.
出版信息
Neurochem Res. 1991 Sep;16(9):1031-6. doi: 10.1007/BF00965847.
PMID:1784330
Abstract
Tetrahydrobiopterin and the folate coenzymes can reciprocally interact in ways that would be useful to the metabolic pathways subserved by both of these coenzymes. Thus, through one of the reactions catalyzed by methylene tetrahydrofolate reductase, 5-CH3-H4-folate can regenerate BH4 from q-BH2 and q-BH2 can provide an escape from the "methyl trap."
摘要
四氢生物蝶呤和叶酸辅酶可以以对这两种辅酶所支持的代谢途径有用的方式相互作用。因此，通过亚甲基四氢叶酸还原酶催化的反应之一，5-CH3-H4-叶酸可以从q-BH2再生四氢生物蝶呤，并且q-BH2可以提供一种摆脱“甲基陷阱”的途径。
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