Pomar Blanco P, San Román Carbajo J, Bouso Montero M, Martín Villares C, Fernández Pello M, Tapia Risueño M
Servicio de ORL, Hospital de eL Bierzo, Ponferrada, León.
An Otorrinolaringol Ibero Am. 2007;34(4):349-58.
Mucosal melanomas of the nasal cavity and paranasal sinuses are rare and agresive neoplasms and carries a bad prognosis. The diagnosis may require confirmatory immunohistochemical stains (S-100 protein, HMB-45, vimentin and cytokeratine). The clinical records of 6 patients with the diagnosis of sinonasal melanomas between 1991 and 2005 were retrospectively reviewed. The mean age was 70 years (range 51 to 83 years), there were 2 men and 4 women. Surgery was performed in four patients, adjuvant radiation therapy was used in one patient after local recurrence and chemotherapy in three patients. Three of four patients (75%) had a recurrence after previous treatment (surgery). The actuarial disease-free survival for this group of 6 is 33.3% (2 of 6). Mucosal melanoma of the head and neck remains a difficult disease to treat, with high locoregional recurrence rates and poor prognosis.
鼻腔和鼻窦黏膜黑色素瘤是罕见且侵袭性强的肿瘤，预后较差。诊断可能需要进行免疫组化染色确诊（S-100蛋白、HMB-45、波形蛋白和细胞角蛋白）。对1991年至2005年间诊断为鼻窦黑色素瘤的6例患者的临床记录进行了回顾性分析。平均年龄为70岁（范围51至83岁），男性2例，女性4例。4例患者接受了手术，1例患者在局部复发后接受了辅助放疗，3例患者接受了化疗。4例患者中有3例（75%）在先前治疗（手术）后复发。这6例患者的无病生存率为33.3%（6例中的2例）。头颈部黏膜黑色素瘤仍然是一种难以治疗的疾病，局部复发率高，预后差。
