Ebihara Itaru, Sato Takashi, Hirayama Kouichi, Seki Masanori, Enami Terukazu, Kawahara Hirohisa, Niwayama Jun, Miyahara Takaaki, Shibata Masamichi, Maeda Nobuki, Kurosawa Takesi, Yamagata Kunihiro, Sanaka Tsutomu
Department of Nephrology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan.
Ther Apher Dial. 2007 Oct;11(5):325-30. doi: 10.1111/j.1744-9987.2007.00497.x.
The presence of peripheral arterial disease substantially increases the risk for both morbidity and mortality among end-stage renal disease patients. Low-density lipoprotein (LDL) apheresis has been also applied for the treatment of peripheral arterial disease to reduce LDL levels, resulting in the improvement of the blood flow to the ischemic limbs. In this study, we investigated the continuous changes of the tissue blood flows in the lower limbs and head during LDL-apheresis treatment by a non-invasive method (the non-invasive continuous monitoring method (NICOMM) system). In this study, the tissue blood flow in both the head and lower limbs showed a significantly enhancement from before to after treatment. The tissue blood flow in the lower limbs showed a significantly larger improvement than that in the head. The short-term effects of LDL apheresis were confirmed by using the NICOMM system; thus, this system will be useful for the determination of the appropriate schedule of LDL apheresis for long-term effectiveness.
外周动脉疾病的存在显著增加了终末期肾病患者发病和死亡的风险。低密度脂蛋白（LDL）单采术也已应用于外周动脉疾病的治疗，以降低LDL水平，从而改善缺血肢体的血流。在本研究中，我们通过一种非侵入性方法（非侵入性连续监测方法（NICOMM）系统）研究了LDL单采术治疗期间下肢和头部组织血流的持续变化。在本研究中，头部和下肢的组织血流在治疗前后均显示出显著增强。下肢的组织血流改善明显大于头部。通过使用NICOMM系统证实了LDL单采术的短期效果；因此，该系统将有助于确定LDL单采术的合适疗程以实现长期疗效。
