Micronization by means of supercritical fluids: possibility of application to pharmaceutical field.

The state of the art in drug micronization is briefly reviewed. The Authors propose and discuss the adoption of a new micronization technique based on supercritical fluids properties: high solvent power and selectivity, fast solute precipitation. A supercritical spray apparatus that has been designed to maximize micronization of pharmaceutical interest products is described. A preliminary scanning of supercritical solvents and cosolvents suitable to dissolve poorly soluble products is also proposed.