Kreeger T J, Levine A S, Seal U S, Callahan M, Beckel M
Department of Ecology, Evolution, and Behavior, University of Minnesota, Minneapolis 55455.
Pharmacol Biochem Behav. 1991 Jul;39(3):559-61. doi: 10.1016/0091-3057(91)90127-n.
Diazepam doses of 0.2, 0.4, and 0.8 mg/kg induced feeding in sated gray wolves in a dose-dependent manner (p less than 0.001). Neither 0.8 mg/kg of the benzodiazepine antagonist, beta-CCP (p = 0.36), nor 0.8 mg/kg of the benzodiazepine inverse agonist, beta-CCE (p = 0.85), decreased the diazepam-induced hyperphagia. Five of 6 naive wolves (p = 0.003) ate dry dog food within 15.4 +/- 1.9 min of being given 0.4 mg/kg diazepam and freely chose dog food after the single diazepam administration.
0.2、0.4和0.8毫克/千克剂量的地西泮以剂量依赖的方式诱导饱食的灰狼进食（p小于0.001）。0.8毫克/千克的苯二氮䓬拮抗剂β-CCP（p = 0.36）和0.8毫克/千克的苯二氮䓬反向激动剂β-CCE（p = 0.85）均未降低地西泮诱导的摄食亢进。6只未接触过药物的狼中有5只（p = 0.003）在给予0.4毫克/千克地西泮后的15.4±1.9分钟内吃了干狗粮，且在单次给予地西泮后自由选择了狗粮。
